Poster AND ORAL PRESENTATION Abstracts:
Sadko K, Bailie M, Leishman D, Lauver A. A Simple, Accurate Method for Determining Concentration-QTc in Animals. Safety Pharmacology Society Annual Meeting. Brussels, Belgium, 2023
Rockwell C, McDonald P, Chowdhury A, Awali S, Jin Y, Boss A, Sather L, Lauver A. Differences In Immune Cell Composition And Response Between Spontaneously Hypertensive Bph/2 Mice And Normotensive Bpn/3 Mice. Hypertension Scientific Sessions. Boston, Massachusetts, 2023
Jin Y, Christian B, Lauver A, Rockwell C. Proinflammatory Cytokine Production By Activated T Cells Cultured In PVAT-conditioned Media From Dahl S Rats On A High Fat Diet Correlates With The Development Of Hypertension. Hypertension Scientific Sessions. Boston, Massachusetts, 2023
Rendon CJ, Sempere L, Lauver A, Watts SW, Contreras GA. Adipocyte Progenitor Subtypes in Perivascular Adipose Tissues: Effect of Site and Spatial Location. Hypertension Scientific Sessions. Boston, Massachusetts, 2023
Wilson C, Thompson J, Terrian L, Lauver A, Flood E, Fink G, Sather L, Bhattacharya S, Contreras A, Watts S. What a difference hypertension makes: the adventitia hands off to PVAT for extracellular matrix remodeling as blood pressure rises in the high fat fed Dahl SS rat. Hypertension Scientific Sessions. Boston, Massachusetts, 2023
Rendon C, Sempere L, Lauver A, Watts S, Contreras A. Understanding Adipocyte Progenitor Subtypes in Perivascular Adipose Tissue: Depot and Spatial Patterns. Hypertension Scientific Sessions. Boston, Massachusetts, 2023
Marroquin M, Onunkun A, Christian B, Lauver A. Unveiling the Effects of Ticagrelor on Bleeding: A Study in P2Y12 Deficient Mice. Mid-Michigan Symposium for Undergraduate Research Experiences (Mid-SURE). East Lansing, Michigan, 2023
Martinez V, Onunkun A, Christian B, Lauver A. Evaluating the Bleeding Effects of Specific Clopidogrel Metabolites. Mid-Michigan Symposium for Undergraduate Research Experiences (Mid-SURE). East Lansing, Michigan, 2023
Rabanus T, Kuszynski D, Christian B, Lauver A. Clopidogrel Induces More Bleeding in P2Y12-deficient Mice: Optimization of Murine Tail Bleeding Assay. American Society for Pharmacology and Experimental Therapeutics Annual Meeting. St. Louis, Missouri, 2023
Leishman D, Bailie M, Lauver A. Comparing the impact of different heart rate correction methods on the sensitivity of QTc assessment in nonhuman primates. Society of Toxicology Annual Meeting. Nashville, Tennessee, 2023
Kim E, Goswami D, Roney A, Okoyeocha E, Lundback S, Kuszynski D, Agarwal R, Lauver A, Tewari-Singh N. Acute and Long-term Hematologic Changes from Dermal Exposure to Mustard Vesicating Agent in Murine Models. Society of Toxicology Annual Meeting. Nashville, Tennessee, 2023
Kuszynski DS, Christian BD, Lauver DA. The Vascular Effect of Clopidogrel. Midwest Platelet Conference. Ann Arbor, Michigan, 2022.
Bailie M, Ether N, Lauver A, Leishman D. How The Assumptions Of A Rate Correction Method Impact Accuracy And Precision Of QTc. Safety Pharmacology Society Annual Meeting. Montreal, Quebec, Canada, 2022
Bailie M, Ether N, Lauver A, Leishman D. The Normal Time Dependent Distribution Of Heart Rate In Conscious Animals Challenges The Assumptions Of Rate Correction Methods And Impacts Accuracy And Precision Of QTc Assessments. Safety Pharmacology Society Annual Meeting. Montreal, Quebec, Canada, 2022
Bailie M, Ether N, Lauver A, Leishman D. The Interaction Of The Time-Action Profile Of Drugs, The Time-Dependent Distribution Of Heart Rates And The Assumption Of Rate Correction Methods All Impact Accuracy And Prevision Of QTc Assessment – If All The Models Are Wrong Which Is Useful? Safety Pharmacology Society Annual Meeting. Montreal, Quebec, Canada, 2022
Fink G, Xu Hui, Fernandes R, Garver H, Lauver A, Watts S. Dahl Salt-sensitive And Salt-resistant Rats Exhibit Highly Disparate Blood Pressure Responses To Lifetime High Fat Diet Feeding. Hypertension Scientific Sessions. San Diego, California 2022.
Hughes E, Bailie M, Leishman D, Lauver A. Developing a translational Model of Moxifloxacin-Induced QT Interval Prolongation. Mid-Michigan Symposium for Undergraduate Research Experiences (Mid-SURE). East Lansing, Michigan, 2022
Rabanus T, Kuszynski D, Christian B, Lauver A. Clopidogrel Induces More Bleeding In P2Y12-Deficient Mice. Mid-Michigan Symposium for Undergraduate Research Experiences (Mid-SURE). East Lansing, Michigan, 2022
Kim E, Goswami D, Roney A, Okoyeocha E, Lundback S, Kuszynski D, Lauver A, Tewari-Singh N. Hematological Consequences of Dermal Exposure to Vesicating Chemical Threat Agent. Mid-Michigan Symposium for Undergraduate Research Experiences (Mid-SURE). East Lansing, MI, 2022
Kuszynski DS, Rollinger M, Thomas J, Dorrance AM, Lauver DA. Clopidogrel’s Effect on the Adverse Cerebral Vascular Effects Associated with Angiotensin II-Induced Hypertension. Annual Meeting of the Federation of American Societies for Experimental Biology, Philadelphia, PA, 2022
Ether N, Bailie M, Leishman D, Lauver A. The “Best” QT Correction You Are Not Using? Society of Toxicology Annual Meeting. San Diego, CA, 2022
Ether N, Bailie M, Leishman D, and Lauver DA. Is QT Correction Necessary? Safety Pharmacology Society Annual Meeting. Virtual, 2021
Kuszynski DS, Christian BD, Dorrance AM, Lauver DA. Endothelial P2Y2-mediated Vasoconstriction is Inhibited in Middle Cerebral Arteries of Rabbits Treated with Clopidogrel. Annual Meeting of the Federation of American Societies for Experimental Biology, Virtual, 2021
Ether N, Bailie M, Leishman D, Lauver A. Which QT Correction Method is Most Consistent? Annual Meeting of the Federation of American Societies for Experimental Biology, Virtual, 2021
Ether N, Bailie M, Leishman D, and Lauver DA. Assessing the Background Rate and Variance of Arrhythmias in Non-Human Primates Using Different Analysis Tools. Safety Pharmacology Society Annual Meeting. Virtual. 2020
Kuszynski DS, Christian BD, Dorrance AM, Lauver DA. Purinergic Receptor Function in the Middle Cerebral Artery from Clopidogrel-Treated Rabbits. Hypertension Scientific Sessions. Virtual, 2020.
Ether N, Bailie M, Leishman D, Lauver A. Effects of ECG Summarization Methods on the Characterization of Drug-Induced QT Prolongation – a Demonstration of Need for Standard Methods of ECG Beat Summarization. Annual Meeting of the Federation of American Societies for Experimental Biology, Virtual, 2020
Kuszynski DS, Christian BD, Dorrance AM, Lauver DA. A Comparative Analysis of the Vascular Effects of Clopidogrel Metabolites. Annual Meeting of the Federation of American Societies for Experimental Biology, Virtual, 2020
Contreras A, Watts S, Lauver A, Garver H, Fink G. Tangential Wall Stress In The Thoracic Aorta Affects The Structure And Function Of Associated Perivascular Adipose Tissue. Hypertension Scientific Sessions. New Orleans, 2019.
Ether N, Bailie M, Leishman D, Lauver A. Evaluating the Impact of Electrocardiogram Analysis Methods on the Accurate Identification of Drug-Induced Changes to QT-Interval. Safety Pharmacology Society Annual Meeting, Barcelona, Spain, 2019
Henderlong DS, Christian BD, Deters MR, Lauver DA. Mechanistic Difference in the Antiplatelet Effects of DT-678 and Existing P2Y12 Antagonists. Annual Meeting of the Federation of American Societies for Experimental Biology, Orlando, Florida, 2019
Ether N, Bailie M, Leishman D, Lauver A. Improving the Prediction of Torsade de Pointes Risk During Drug Discovery and Development. Safety Pharmacology Society Annual Meeting, Washington, D.C., 2018
Lauver A, Abolibdeh B, Bailie M, Leishman D. Action Potential Plateau Phase Metrics in Predictive Models of Arrhythmia Potential. Safety Pharmacology Society Annual Meeting, Washington, D.C., 2018
Henderlong D, Christian B, Teuber J, Lauver A. Determining the Efficacy and Safety of DT-678, A Novel Conjugate of Clopidogrel, in Rabbits. 45th Annual Pharmacology Research Colloquium, Michigan State University, East Lansing, MI, 2018
Lauver DA, Parch JI, Gurm HS. Discontinuation of Chronic RAAS Inhibitor Therapy at Time of Contrast Media Administration Reduces Degree of Kidney Injury in an Animal Model. Annual Meeting of the Federation of American Societies for Experimental Biology, Chicago, Illinois, 2017
Lauver DA, Lucchesi BR, Gurm HS. Sildenafil citrate attenuates acute renal injury in an animal model of contrast-induced nephropathy. Annual Meeting of the Federation of American Societies for Experimental Biology, San Diego, California, 2014
Qiao C, Lauver DA, Lucchesi BR. Atorvastatin-induced cardiac function impairment. Annual Meeting of the Federation of American Societies for Experimental Biology, Boston, Massachusetts, 2013
Lauver DA, Silapaswan AM, Patel KD, Lucchesi BR. A novel glutathione preparation protects the ischemic rabbit isolated heart after oral administration. Annual Meeting of the Federation of American Societies for Experimental Biology, Washington, District of Columbia, 2011
Lauver DA, Frieler RA, Smith WL, and Lucchesi BR. Celecoxib administration interferes with the anti-platelet effect of low dose aspirin in canines. Annual Meeting of the Federation of American Societies for Experimental Biology, Anaheim, California, 2010
Lauver DA, Driscoll EM, and Lucchesi BR. RO3244794, an IP receptor antagonist, shortens the time to occlusion in a canine model of coronary artery thrombosis. Annual Meeting of the Federation of American Societies for Experimental Biology, San Diego, California, 2008
Lauver DA, Hong TT, Driscoll EM, and Lucchesi BR. Characterization of RO3244794, a novel selective prostacyclin receptor antagonist. Midwest Pharmacology Colloquium, University of Toledo Medical Campus, Toledo, Ohio, 2007
Lauver DA, and Lucchesi, BR. CardaxÔ (disodium disuccinate astaxanthin) attenuates myocardial injury following ischemia/reperfusion. Annual Meeting of the Federation of American Societies for Experimental Biology, San Diego, California, 2005
Lauver DA and Lucchesi BR. Sulodexide attenuates myocardial ischemia/reperfusion injury without prolonging activated partial thromboplastin time. Annual Meeting of the Federation of American Societies for Experimental Biology, Washington, District of Columbia, 2004
Lauver DA, Booth EA, White AJ, and Lucchesi BR. 17b-estradiol reduces the expression of C-reactive protein and the formation of the membrane attack complex after ischemia/ reperfusion. Midwest Pharmacology Colloquium, University of Michigan, Ann Arbor, Michigan, 2003